Programmable Excitonic Systems on DNA Nanostructures Excitons are mediators in both absorption and emission of light. Mastering the flow of excitons is the “holy grail” of light-harvesting systems, which include photovoltaic devices and microscopy probes. I am programming DNA nanostructures for control of nanoscale energy transport and investigation of new optical properties.
Dr. William P. Bricker
Ph.D., Energy, Environmental & Chemical Engineering, Washington University in St. Louis
Excitonics of Multi-chromophore-DNA Assemblies
I am designing and analyzing DNA-based multi-chromophore assemblies for nanoscale energy transfer, light-harvesting and biosensing applications.
Structured DNA Assemblies for Vaccines and Delivery
I am using structured DNA assemblies to organize antigens, peptides, and lipids for immune cell stimulation in vaccine development and targeted cellular delivery.
DNA Nanotechnology for Targeted Delivery
I am interested in using DNA nanotechnology to develop programmable delivery platforms. The controlled organization of ligands and cargo provides unique opportunities to engineer cell-specific targeting, intracellular trafficking and cargo release.
Structural DNA Nanotechnology
DNA can be programmed to self-assemble into diverse nanoscale geometries. Functionality can be programmed by scaffolding secondary molecules to create systems such as multi-enzyme cascades, biological delivery vehicles, and nanoscale energy transport systems. I am using a combination of computational modeling and experiment to distill thermodynamic principles driving folding pathways and stability of these assemblies.