Associate Professor, Department of Biological Engineering, MIT
Associate Member, Broad Institute of MIT & Harvard
Member, MIT Center for Environmental Health Sciences
Member, MIT Center for Excitonics
Member, MIT Center for Neurobiological Engineering
Programmable Excitonic Systems on DNA Nanostructures Excitons are mediators in both absorption and emission of light. Mastering the flow of excitons is the “holy grail” of light-harvesting systems, which include photovoltaic devices and microscopy probes. I am programming DNA nanostructures for control of nanoscale energy transport and investigation of new optical properties.
Dr. William P. Bricker
Ph.D., Energy, Environmental & Chemical Engineering, Washington University in St. Louis
Excitonics of Multi-chromophore-DNA Assemblies
I am designing and analyzing DNA-based multi-chromophore assemblies for nanoscale energy transfer, light-harvesting and biosensing applications.
Phenotypic Profiling of Neuronal Synaptic Proteins
Synaptic proteins regulate a wide range of activities central to neurotransmission including homeostasis, trans-synaptic cell-adhesion, and vesicle-mediated neurotransmitter release. I am using multiplexed fluorescence imaging to characterize synaptic proteins in neuronal circuits using nucleic acid based imaging probes.
Dr. Hyungmin Jun
Ph.D., Engineering Mechanics, Korea Advanced Institute of Science and Technology (KAIST)
Structural DNA Nanotechnology
I am developing sequence design procedures to render arbitrary 3D nanostructures using synthetic DNA.
Cell Classification using Multiplexed Immunophenotyping
Multicellular tissue environments contain a diverse mixture of cellular classes and states, for example, the tumor microenvironment consists of genetically diverse tumor cells as well as immune cells and normal stroma. I utilize multiplexed fluorescent imaging enabled by DNA barcoding to classify cells in complex tissue environments. I then teach computer vision systems to recognize these cellular classes in common histology images, enabling detailed characterization of the tumor microenvironment and other complex tissue environments.
Dr. Martin Tomov Ph.D., Nanoscale and Materials Engineering, University at Albany, SUNY
Co-advised by Lee Rubin, Harvard Stem Cell Institute
Phenotypic Profiling of iPSC-derived Neurons
I am designing microfluidic systems to enable multiplexed fluorescence imaging of iPSC-derived neurons to model psychiatric disease.
Structured DNA Assemblies for Vaccines and Delivery
I am using structured DNA assemblies to organize antigens, peptides, and lipids for immune cell stimulation in vaccine development and targeted cellular delivery.
Structural DNA Nanotechnology
DNA can be programmed to self-assemble into diverse nanoscale geometries. Functionality can be programmed by scaffolding secondary molecules to create systems such as multi-enzyme cascades, biological delivery vehicles, and nanoscale energy transport systems. I am using a combination of computational modeling and experiment to distill thermodynamic principles driving folding pathways and stability of these assemblies.