Principal Investigator

Mark Bathe
Associate Professor, Department of Biological Engineering, MIT
Associate Member, Broad Institute of MIT & Harvard
Member, MIT Center for Environmental Health Sciences
Member, MIT Center for Excitonics
Member, MIT Center for Neurobiological Engineering

bio ] [ cv ] [ e-mail ]

Administrative Assistant

Pam Fradkin
Administrative Assistant
Department of Biological Engineering

Postdoctoral Researchers

Dr. James L. Banal
Ph.D., Physical and Materials Chemistry, University of Melbourne

Programmable Excitonic Systems on DNA Nanostructures
Excitons are mediators in both absorption and emission of light. Mastering the flow of excitons is the “holy grail” of light-harvesting systems, which include photovoltaic devices and microscopy probes. I am programming DNA nanostructures for control of nanoscale energy transport and investigation of new optical properties.

Dr. Zachary Barry
Ph.D., Biological Engineering, MIT
Co-advised by Ethan Garner, Harvard University

Bacterial Cell Wall Synthesis
Peptidoglycan synthesis plays a central role in bacterial cell growth. I am applying super-resolution fluorescence imaging in collaboration with the Garner lab to extract chemical mechanisms of cell wall growth using single-particle trajectory analysis, fluorescence fluctuation analysis, and Bayesian inference.

Dr. William P. Bricker
Ph.D., Energy, Environmental & Chemical Engineering, Washington University in St. Louis

Excitonics of Multi-chromophore-DNA Assemblies
I am designing and analyzing DNA-based multi-chromophore assemblies for nanoscale energy transfer, light-harvesting and biosensing applications.

Dr. Syuan-Ming Guo
Ph.D., Chemistry, MIT

Phenotypic Profiling of Neuronal Synaptic Proteins
Synaptic proteins regulate a wide range of activities central to neurotransmission including homeostasis, trans-synaptic cell-adhesion, and vesicle-mediated neurotransmitter release. I am using multiplexed fluorescence imaging to characterize synaptic proteins in neuronal circuits using nucleic acid based imaging probes.

Dr. Hyungmin Jun
Ph.D., Engineering Mechanics, Korea Advanced Institute of Science and Technology (KAIST)

Structural DNA Nanotechnology
I am developing sequence design procedures to render arbitrary 3D nanostructures using synthetic DNA.

Dr. Tyson Shepherd
Ph.D., Biochemistry, University of Iowa

DNA and RNA Nanotechnology
I am developing design and synthesis approaches to engineer structured DNA and RNA assemblies for applications in biomolecular science and technology.

Dr. Matthew Stone
Ph.D., Biophysics, University of Michigan

Cell Classification using Multiplexed Immunophenotyping
Multicellular tissue environments contain a diverse mixture of cellular classes and states, for example, the tumor microenvironment consists of genetically diverse tumor cells as well as immune cells and normal stroma. I utilize multiplexed fluorescent imaging enabled by DNA barcoding to classify cells in complex tissue environments. I then teach computer vision systems to recognize these cellular classes in common histology images, enabling detailed characterization of the tumor microenvironment and other complex tissue environments.

Dr. Martin Tomov
Ph.D., Nanoscale and Materials Engineering, University at Albany, SUNY
Co-advised by Lee Rubin, Harvard Stem Cell Institute

Phenotypic Profiling of iPSC-derived Neurons
I am designing microfluidic systems to enable multiplexed fluorescence imaging of iPSC-derived neurons to model psychiatric disease.

Dr. Rémi Veneziano
Ph.D., Biology-Health, University of Montpellier II

Structured DNA Assemblies for Vaccines and Delivery
I am using structured DNA assemblies to organize antigens, peptides, and lipids for immune cell stimulation in vaccine development and targeted cellular delivery.

Graduate Students

Joseph Berleant
Ph.D. Candidate, Biological Engineering

Programming Dynamic Hierarchical DNA Assemblies
Stay tuned!

Rebecca Du
Ph.D. Candidate, Biological Engineering

DNA and RNA Therapeutics 
Stay tuned!

Molly Parsons
Ph.D. Candidate, Biological Engineering

Mapping 3D Structure of Long RNAs
Stay tuned!

Sakul Ratanalert
Ph.D. Candidate, Chemical Engineering

Structural DNA Nanotechnology
DNA can be programmed to self-assemble into diverse nanoscale geometries. Functionality can be programmed by scaffolding secondary molecules to create systems such as multi-enzyme cascades, biological delivery vehicles, and nanoscale energy transport systems. I am using a combination of computational modeling and experiment to distill thermodynamic principles driving folding pathways and stability of these assemblies.

Undergraduate Students

Claire Goul
Sophomore, Computer Science & Biology

Habiba Noamany
Freshman

Kaitlin Tucci
Freshman

Alumni

Matthew Adendorff
Co-founder GMA Innovations
Lead Technologist Open Data Durban

Etienne Boulais
Postdoctoral Research Associate
University of Montreal

Philip Bransford
Vertex Pharmaceuticals, Inc.

Arkajit Dey
Twitter, Inc.

Philipp Diesinger
Management Consultant

Changsun Eun
Samsung, Inc.

Stavros Gaitanaros
Assistant Professor
Johns Hopkins University

Simon Gordonov
Vertex Pharmaceuticals, Inc.

Jun He
Opera Solutions, Inc.

Do-Nyun Kim
Assistant Professor
Seoul National University

Aprotim Mazumder
Assistant Professor
TCIS, TIFR Hyderabad

Nilah Monnier
Computational, Evolutionary, and Human Genomics Postdoctoral Research Fellow Stanford University

Keyao Pan
Boston Biomedical, Inc.

Elizabeth Perley
Software Engineer
Google, Inc.

Reza Sharifi Sedeh
General Electric Research, Inc.

Kirill Titievsky
Google, Inc.

Lun Yang
The MathWorks, Inc.

[ back to top ]