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The mission of the Laboratory for Computational Biology & Biophysics is to develop robust, innovative computational technologies that enable molecular-level understanding and engineering of biological systems. Toward this end, we focus on high information-content biological datasets including fluorescence light microscopy, electron microscopy, and high-throughput sequencing to understand and control nucleic acid structure and function, and molecular dynamics mediating diverse cellular processes. Computational analysis of these datasets drives the generation and systematic evaluation of mechanistic biological models that are firmly rooted in chemistry and physics, which are subsequently tested using molecular perturbations, including the use of functionalized nucleic acid nanostructures. For specific applications of this workflow please see our accompanying research and publications pages. |
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